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  • Title: Crystallization and preliminary X-ray diffraction studies of human epidermal growth factor.
    Author: Chai JJ, Li M, Huang BR, Luo Y, Luo M, Bi RC, He CH.
    Journal: Acta Crystallogr D Biol Crystallogr; 2000 Jan; 56(Pt 1):62-3. PubMed ID: 10666628.
    Abstract:
    Human epidermal growth factor (hEGF), a 6.2 kDa protein of 53 amino acids with three internal disulfide bridges, has been crystallized by the hanging-drop method. hEGF crystallizes in space group P3(1)21 (or P3(2)21) using MgCl(2) as precipitant, with unit-cell parameters a = b = 61.4, c = 87.0 A. Another type of crystal, obtained using NaCl as precipitant, belongs to a tetragonal point group and has unit-cell dimensions a = b = 102.5, c = 166.6 A. The trigonal crystals with the smaller unit cell diffract X-rays better and a native data set from a single crystal has been collected to 3.0 A resolution.
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