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  • Title: No induction of apoptosis by IFN-beta in human antigen-specific T cells.
    Author: Zipp F, Beyer M, Gelderblom H, Wernet D, Zschenderlein R, Weller M.
    Journal: Neurology; 2000 Jan 25; 54(2):485-7. PubMed ID: 10668719.
    Abstract:
    Interferon (IFN)-beta, the most effective immunomodulatory treatment for MS, inhibits the proliferation of myelin-specific T cells. We report that IFN-beta moderately enhances the expression of the death receptor, CD95, at the surface of human antigen-specific T cells. However, T-cell apoptosis was not induced by IFNbeta-1a or IFNbeta-1b as assessed by caspase activity or DNA fragmentation. Immunomodulation mediated by IFN-beta does not directly involve apoptotic pathways in human T cells.
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