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  • Title: Experimental study of the effects on apoptosis of docetaxel alone and in combination with irradiation.
    Author: Matsuura M, Hasegawa M, Hayakawa K, Kawashima M, Nasu S, Nakamura Y, Hayakawa K, Mitsuhashi N, Niibe H.
    Journal: Oncol Rep; 2000; 7(2):289-93. PubMed ID: 10671673.
    Abstract:
    The effects of docetaxel alone and in combination with irradiation were experimentally investigated in terms of induction of apoptosis. A human ependymoblastoma was transplanted into nude mice, and they were intravenously injected with docetaxel, followed or preceded by irradiation with a single dose of 2 Gy. Apoptosis was less common in the docetaxel-alone group than in the irradiation-alone group. When administration of docetaxel was followed by irradiation, apoptosis was equal to or less common than in the irradiation-alone group. Apoptosis was most common in the irradiation-followed-by-docetaxel group. The incidence of mitosis was lower in the irradiation-alone group and the irradiation-followed-by-docetaxel group than in the docetaxel-alone group and the docetaxel-followed-by-irradiation group. The combined effect of irradiation and docetaxel appears to be useful in inducing apoptosis, but the sequence of irradiation and docetaxel is important.
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