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  • Title: Modulation of ribonuclease P activity by calcipotriol.
    Author: Papadimou E, Monastirli A, Stathopoulos C, Tsambaos D, Drainas D.
    Journal: Eur J Biochem; 2000 Feb; 267(4):1173-7. PubMed ID: 10672028.
    Abstract:
    The effects of cholesterol, 7-dehydrocholesterol, vitamin D3 and several synthetic vitamin D3 analogs on ribonuclease P (RNase P) were investigated using a cell-free system from the slime mold Dictyostelium discoideum. RNase P is an ubiquitous and essential enzyme that endonucleolytically cleaves all tRNA precursors to produce the mature 5' end. Among the compounds tested, only calcipotriol was capable of affecting RNase P activity, and revealed a bimodal action at the kinetic phase of the reaction. Depending on the concentration of the drug, both activation and inhibition of tRNA maturation were observed, indicating that calcipotriol may have a direct effect on tRNA biogenesis, possibly associated with the presence of a highly reactive small ring on the side chain of its molecule.
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