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  • Title: Lack of association between ACE gene polymorphism and left ventricular hypertrophy in essential hypertension.
    Author: Gomez-Angelats E, de la Sierra A, Enjuto M, Sierra C, Oriola J, Francino A, Paré JC, Poch E, Coca A.
    Journal: J Hum Hypertens; 2000 Jan; 14(1):47-9. PubMed ID: 10673731.
    Abstract:
    The possible association between the insertion/deletion (I/D) polymorphism of the angiotensin I converting enzyme (ACE) gene and left ventricular hypertrophy (LVH) was investigated in a group of essential hypertensive patients. Seventy-one essential hypertensive patients (35 men and 36 women), aged 51 +/- 1 years, were genotyped by PCR for the I/D polymorphism of the ACE gene. Cardiac morphology and function were assessed by means of M-mode echocardiography. The relative frequencies of the three genotypes, DD, DI, and II, were respectively: 24%, 55%, and 21%. Mean values of left ventricular mass index were 145, 144, and 150 g/m2 for DD, DI, and II genotypes, without significant differences among them (P = 0.82). Likewise, the prevalence of LVH (76%, 64%, and 87%) was not significantly different among the three genotypes (P = 0.23). We conclude that the ACE gene I/D polymorphism is not associated with LVH in essential hypertension. Journal of Human Hypertension (2000) 14, 47-49.
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