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  • Title: Reconstruction of human hard-palate mucosal epithelium on de-epidermized dermis.
    Author: Cho KH, Ahn HT, Park KC, Chung JH, Kim SW, Sung MW, Kim KH, Chung PH, Eun HC, Youn JI.
    Journal: J Dermatol Sci; 2000 Feb; 22(2):117-24. PubMed ID: 10674825.
    Abstract:
    Artificial hard-palate mucosa equivalents were reconstructed using keratinocytes derived from normal human hard-palate and de-epidermized dermis. Reconstructed hard-palate mucosal epithelium formed in three-dimensional culture was compared to native hard-palate mucosal epithelium and reconstructed oral buccal mucosal epithelium with regard to keratin expression. Artificial hard-palate mucosal epithelium reconstructed in medium with delipidized serum showed a differentiation pattern similar to that of hard-palate epithelium in vivo. The present study also confirmed that keratinocytes derived from hard-palate mucosa are intrinsically different from those of nonkeratinizing oral surfaces.
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