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Title: Comparative effects of quaternary ammonium mouthrinses on 4-day plaque regrowth. Author: Moran J, Addy M, Jackson R, Newcombe RG. Journal: J Clin Periodontol; 2000 Jan; 27(1):37-40. PubMed ID: 10674960. Abstract: BACKGROUND: Quaternary ammonium compounds constitute a large group of antibacterial chemicals with a potential for inhibiting plaque and gingivitis. One compound, benzalkonium chloride (BC), may be of value, although there is a dearth of evidence to support efficacy. The aim of this study was to measure the ability of 2 BC mouthrinses (0.05% and 0.1%) to inhibit de novo plaque reformation. METHOD: A 4-day plaque regrowth model. For comparative purposes, a commercial mouthrinse containing cetyl pyridinium chloride (CPC) and a positive control chlorhexidine (CX) mouthrinse were also evaluated. RESULTS: Compared to water control, a reduction in plaque scores of 52% was noted for the CX mouthrinse, 22.5% for CPC and 5% and 6% for the 2 BC rinses. For plaque area, reductions of 84%, 47%, 16% and 15% were found for CX, CPC, and the 2 BC rinses, respectively. Significant reductions in plaque area compared to the water rinse were also seen with the 2 BC rinses (p<0.05). However, for both plaque score and plaque area, the CX and CPC rinses significantly reduced plaque compared to the BC rinses (p<0.0001). CONCLUSIONS: These findings would suggest that the 2 benzalkonium rinses would only have a limited value at inhibiting plaque formation.[Abstract] [Full Text] [Related] [New Search]