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  • Title: Characterisation of the proximal regulatory domain of the Echinococcus granulosus homeodomain-containing gene EgHbx1.
    Author: Esperón P, Gorfinkiel N, Garat B, Ehrlich R.
    Journal: Int J Parasitol; 2000 Jan; 30(1):45-9. PubMed ID: 10675743.
    Abstract:
    In an attempt to understand the molecular basis of the development of Echinococcus granulosus, we have previously isolated several homeobox-containing genes (EgHbx1-5). Here we report the characterisation of the EgHbx1 proximal regulatory domain. EgHbx1 codes for an amino acid sequence presenting 90% identity at the homeodomain level with the Drosophila melanogaster NK1-S59 transcription factor. The proximal regulatory domain sequence and the transcription start site were determined. Electrophoretic mobility shift assays using nuclear extracts from protoscoleces revealed the presence of specific DNA-protein complexes. These results constitute a hint and provide new tools to decipher regulatory cascades during E. granulosus development.
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