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  • Title: Influenza virus genome consists of eight distinct RNA species.
    Author: McGeoch D, Fellner P, Newton C.
    Journal: Proc Natl Acad Sci U S A; 1976 Sep; 73(9):3045-9. PubMed ID: 1067600.
    Abstract:
    The genomic RNA of the avian influenza A virus, fowl plague, was fractionated into eight species by electrophoresis in polyacrylamide-agarose gels containing 6 M urea. The separated 32P-labeled RNA species were characterized by digestion with RNase T1 and fractionation of the resulting oligonucleotides by two-dimensional gel electrophoresis; this demonstrated that each species has a distinct nucleotide sequence. A tentative correlation of each genome RNA species with the virus protein that it encodes was made.
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