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  • Title: Regression of experimental liver tumor after distant intra-hepatic injection of cytosine deaminase-expressing tumor cells and 5-fluorocytosine treatment.
    Author: Pierrefite-Carle V, Baque P, Gavelli A, Benchimol D, Bourgeon A, Milano G, Saint-Paul MC, Rossi B.
    Journal: Int J Mol Med; 2000 Mar; 5(3):275-8. PubMed ID: 10677568.
    Abstract:
    Cytosine deaminase (CD) gene of E. coli converts the non-toxic compound 5-fluorocytosine (5-FC) into 5-fluorouracil. We have introduced a vector expressing the CD gene in a rat colon carcinoma cell line. Expression of the CD gene confers 5-FC sensitivity to these cells in vitro and in vivo. In a bifocal model consisting in a simultaneous engrafment of a CD+ tumor on one lobe of the liver and a wild-type parental tumor on the opposite lobe, treatment with 5-FC results in regression of both type of tumors, indicating the existence of a distant bystander effect.
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