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  • Title: [nm23 expression and its correlation with lung metastasis in human salivary adenoid cystic carcinoma].
    Author: Shi H, He R, Qiu W.
    Journal: Zhonghua Kou Qiang Yi Xue Za Zhi; 1997 Jan; 32(1):4-6. PubMed ID: 10677933.
    Abstract:
    The nm23 gene products, nucleoside diphosphate kinase (NDPK), expression in salivary adenoid cystic carcinoma (ACC) was evaluted by using LSAB immunohistochemical method. Of 25 cases tested, 16 (64.0%) showed positive staining, in which, higher incidence of positive staining was found in ACC without lung metastasis (88.2%, 15/17) than in that with lung metastasis (12.5%, 1/8; P < 0.01). Expression of NDPK/nm23 was correlated with the P-TNM pattern (P < 0.05), otherwise it was not correlated with pathologic types (P > 0.05). The result suggest that the nm23/NDPK may play a role in suppressing the metastatic potential in ACC.
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