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  • Title: Orphanin FQ/nociceptin inhibits morphine withdrawal.
    Author: Kotlińska J, Suder P, Legowska A, Rolka K, Silberring J.
    Journal: Life Sci; 2000 Jan 14; 66(8):PL119-23. PubMed ID: 10680585.
    Abstract:
    The influence of orphanin FQ/nociceptin (OFQ/N) on the morphine-withdrawal symptom was investigated. Withdrawal syndrome was induced in the morphine-dependent rats by an intraperitoneal (i.p.) injection of 2 mg/kg naloxone hydrochloride--an opioid receptors antagonist. Wet-dog shakes were used as a measure of the abstinence syndrome. Intraventricular injections of OFQ/N (5-20 microg/animal) caused significant inhibition of the withdrawal signs at doses between 15-20 microg, in the morphine-dependent rats. OFQ/N alone did not change behavior of the morphine-dependent animals. The obtained results indicate that OFQ/N can inhibit the morphine withdrawal symptoms induced by naloxone.
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