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Title: Efficacy of SCH56592 in a rabbit model of invasive aspergillosis. Author: Kirkpatrick WR, McAtee RK, Fothergill AW, Loebenberg D, Rinaldi MG, Patterson TF. Journal: Antimicrob Agents Chemother; 2000 Mar; 44(3):780-2. PubMed ID: 10681359. Abstract: SCH56592 (SCH) was evaluated in an immunosuppressed rabbit model of invasive aspergillosis. SCH was more effective than similar doses of itraconazole and as effective as amphotericin B in the clearance of Aspergillus spp. from tissues. Compared with controls, SCH regimens reduced mortality, improved survival, and significantly reduced tissue colony counts.[Abstract] [Full Text] [Related] [New Search]