These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Expression and significance of p53, c-erbB2, CEA proteins in colorectal adenoma and carcinoma].
    Author: Shu M, Liu S, Yu P.
    Journal: Hunan Yi Ke Da Xue Xue Bao; 1998; 23(2):129-32. PubMed ID: 10681823.
    Abstract:
    Expression of p53, c-erB2, CEA proteins in 15 cases of normal colorectal mucosa, 40 adenoma and 40 carcinoma of colon were studied with immunohistochemistry. The positive rate of p53, c-erbB2, CEA in colorectal carcinomas were significantly higher than those in adenoma. The positive rate of p53 in adenoma with severe atypical hyperplasia was higher than that in the mild (P< 0.01), and was higher in colorectal carcinomas of poor differentiation that that in the well-differentiated ones (P< 0.05). The novel type monoclonal antibody of CEA Col-1 had a high sensitivity and specificity for the tissue of colorectal carcinoma in which the positive rate was 85%. The results suggested the alteration p53, c-erbB2 are involve in the tumorgenesis and development of colorectal carcinoma; and detection of p53, c-erbB2 and CEA proteins are helpful in distinguishing benign and malignant polyps of colon.
    [Abstract] [Full Text] [Related] [New Search]