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  • Title: [Study on seroprevalence of Helicobacter pylori infection among upper digestive tract cancer patients and their kindreds].
    Author: Li Z, Gao C, Ding J.
    Journal: Zhonghua Liu Xing Bing Xue Za Zhi; 1999 Apr; 20(2):88-90. PubMed ID: 10682540.
    Abstract:
    OBJECTIVE: In order to analyse the association between Hp infection and the risk of upper-digestive tract cancer. METHODS: In Huaian and Pizhou cities, Jiangsu province, Hp IgG quantitative-enzyme-immunoassay methods was used to identify IgG to H.pylori in the serum of 312 cases of upper-digestive tract cancer patients and their kindreds. RESULTS: (1) The level of IgG to H. pylori and the IgG positive rate (50.0%) in gastric cancer patients were both higher than that of cardia and esophageal cancer patients (P > 0.05, chi 2 test) but no significant differences were observed between cardia and esophageal cancer patients, 3 types of cancer patients and their kindreds; (2) the overall positive rates of both patients and kindreds in gastric cancer families (27.1%) were significantly higher than that of cardia or esophageal cancer families (P < 0.05) but no significant differences were observed between cardia and esophageal groups. CONCLUSION: H.pylori infection was not thought to be correlated with the development of gastric cancer, although higher clustering of Hp infection in families afflicted with gastric cancer was noticed.
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