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  • Title: [Efficacy of beta-carotene on lipid peroxidation induced by N-nitrosodimethylamine in rats].
    Author: Chen Q, Wang S, Mei J, Xu Y.
    Journal: Wei Sheng Yan Jiu; 1998 Mar; 27(2):105-8. PubMed ID: 10682618.
    Abstract:
    The effect of beta-carotene (beta-C) on lipid peroxidation induced by N-nitrosodimethylamine (NDMN) in rats was studied. Thirty clear conventional SD rats were randomly devided into 3 groups and were intragastricly given daily water (10 ml/kg). NDMN (1.75 mg/kg), and NDMN (1.75 mg/kg) plus beta-C (25 mg/kg) respectively. The results showed that: compared with group 1, the activities of SOD and GSH-Px in NDMN group were significantly decreased (P < 0.05), the values of MDA and ROOH increased (P < 0.05). The activities of SOD and GSH-Px in group 3 were significantly higher and the contents of ROOH and MDA were significantly lower than that of NDMN group (P < 0.05). These results suggested that free radicals and lipid peroxidation may be a carcinogenic path for NDMN and other nitrosamines. beta-C had ability to inhibit the lipid peroxidation induced by NDMN.
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