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  • Title: [The expression of tumor suppressor gene p53 and Rb gene in nasopharyngeal carcinoma].
    Author: Song Y, Wang L, Huang G, Huang R, Yuan S, Liu Y.
    Journal: Hua Xi Yi Ke Da Xue Xue Bao; 1997 Sep; 28(3):268-71. PubMed ID: 10684031.
    Abstract:
    In order to observe the relation of tumor supperssor gene p53 and Rb gene to nasopharyngeal carcinoma, we investigated p53 gene mutations in exon 7-8 in 33 cases of nasopharygeal carcinoma (NPC), using single-strand conformation ploymorphism analysis of PCR (PCR-SSCP). The data showed p53 mutations in 7 of 33 specimens at exon 8 (21.2%). No mutation in exon 7 was detected. Analysis of Rb gene in NPC tissues by southern blot revealed the deletion and loss of activity of Rb gene in 11 of 13 cases (86.6%). Our results suggest that Rb gene and p53 gene are closely associated with the tumorigenesis of NPC.
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