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  • Title: [Determination of valaciclovir polybutylcyanoacrylate nanoparticles].
    Author: He Q, Zhang Z.
    Journal: Hua Xi Yi Ke Da Xue Xue Bao; 1998 Sep; 29(3):272-4. PubMed ID: 10684090.
    Abstract:
    The valaciclovir content of polybutylcyanoacrylate nanoparticles was determined by HPLC after dissolving the valaciclovir-poly butylcyanoacrylate nanoparticles in a solvent mixture. ODS-C18 column was used. The mobile phase consisted of CH3OH-0.02 mol/L KH2PO4 (20:80). The linear range was 2.02-20.20 micrograms/ml; the recovery 97.30%, and RSD 4.90%. This method is accurate and can be used for determining the contents of other nanoparticles.
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