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  • Title: [Humoral immunity and antigens of HLA system in acute pancreatitis].
    Author: Trukhan DI, Poluéktov VL.
    Journal: Khirurgiia (Mosk); 2000; (1):8-10. PubMed ID: 10684186.
    Abstract:
    In the authors investigations patients with acute pancreatitis had antibodies to endogenic antigens: to o-DNA--in 58.5%, to d-DNA--in 53.7%, to n-DNA in 51.2%, to trypsin--in 42.7%, to insulin--in 28.1% and to the tissue antigen of the pancreas--in 19.5%. A rise of serum immunoglobulins' and circulating immune complexes' levels were established. Alterations of humoral immunity in connection with high frequency of antigens HLA A1, B8, B18 associated with disregulation among T- and B-links of immune system detected in patients with acute pancreatitis, represent genetic and humoral mechanisms which mediate the development of autoimmune reactions in this disease.
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