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  • Title: Abnormalities in sperm acid glycosidases from infertile men with idiopathic oligoasthenoteratozoospermia.
    Author: Corrales JJ, Burgo RM, Miralles JM, Villar E.
    Journal: Fertil Steril; 2000 Mar; 73(3):470-8. PubMed ID: 10688998.
    Abstract:
    OBJECTIVE: To analyze and compare acid beta-glucuronidase, alpha-mannosidase, alpha-glycosidase, alpha-galactosidase, beta-galactosidase, and beta-N-acetylglucosaminidase activities in fertile and infertile patients. DESIGN: An observational, controlled, clinical study. SETTING: A university tertiary hospital. PATIENT(S): Thirty-six fertile controls, 24 infertile oligoasthenoteratozoospermic (OAT) patients, and 10 azoospermic patients, who served as negative controls. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Analysis of the six glycosidase activities in seminal plasma and in solubilized spermatozoa. RESULT(S): alpha-galactosidase and beta-galactosidase activities in spermatozoa were significantly correlated with the serum levels of gonadotropins both in fertile controls and in OAT patients. The relative contribution of alpha-galactosidase and beta-galactosidase from the soluble fraction of spermatozoa to the total activity measured in the ejaculate of OAT patients was significantly lower than in fertile controls. The activities of beta-galactosidase and beta-N-acetylglucosaminidase in the soluble fraction of spermatozoa from OAT patients were significantly lower than in fertile controls. In seminal plasma, the activity of alpha-mannosidase from OAT patients was significantly higher than in fertile controls. The activity of beta-N-acetylglucosaminidase in the nonsoluble fraction of spermatozoa from OAT patients was three times higher than in fertile controls. CONCLUSION(S): The abnormalities in the distributions and contents of alpha-galactosidase, beta-galactosidase, and beta-N-acetylglucosaminidase in sperm suggest possible functional defects in spermatozoa from OAT infertile patients.
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