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  • Title: Delayed and immediate hypersensitivity reactions associated with the use of amalgam.
    Author: McGivern B, Pemberton M, Theaker ED, Buchanan JA, Thornhill MH.
    Journal: Br Dent J; 2000 Jan 22; 188(2):73-6. PubMed ID: 10689768.
    Abstract:
    Hypersensitivity to the constituents of dental amalgam is uncommon. When it occurs it typically manifests itself as a lichenoid reaction involving a delayed, type IV, cell-mediated hypersensitivity response. Rarely, a more acute and generalised response can occur involving both the oral mucosa and skin. We describe two cases that illustrate the presentation and management of these two types of reaction.
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