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  • Title: [Anxiety and behavior in WAG/Rij strain rats with genetically induced absence attacks].
    Author: Kliueva IuA, Chepurnova NE, Berdiev RK, Mart'ianov AA, Mogimi A, Chepurnov SA.
    Journal: Zh Vyssh Nerv Deiat Im I P Pavlova; 1999; 49(6):1018-26. PubMed ID: 10693282.
    Abstract:
    Behavior of nonlinear rats and animals from Wistar and WAG/Rij (with inborn generalized absence epilepsy) strains was examined in the elevated plus-maze and the hole board. WAG/Rij rats demonstrated low exploratory behavior in both tests. In the elevated plus-maze, WAG/Rij rats were more balanced and more anxious than Wistar and nonlinear rats. Administration of ethosuximide completely eliminated spike-wave discharges but did not change behavioral interstrain differences. Since the spike-wave patterns develop in WAG/Rij at the age of 3 months, the behavior of young (2-moth-old) pups from different strains was compared and significant differences were revealed. Correlation between the genetically defined features (spike-wave discharges) and behavioral peculiarities in WAG/Rij rats is supposed.
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