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  • Title: Motilin effects on gastrointestinal motility and lower esophageal sphincter (LES) pressure in dogs.
    Author: Jennewein HM, Bauer R, Hummelt H, Lepsin G, Siewert R, Waldeck F.
    Journal: Scand J Gastroenterol Suppl; 1976; 39():63-5. PubMed ID: 1069365.
    Abstract:
    Natural porcine motilin induces phasic contractions of the lower esophageal sphincter in dogs. These contractions are related to gastric contractions, which have the characteristics of interdigestive-motility patterns. Duodenal alkalinization produces an insignificant LES pressure increase after 5 minutes. No effect of motilin was observed when using isolated canine muscle strips.
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