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  • Title: Effect of 13-Nle-motilin on small intestinal transit time in healthy subjects.
    Author: Ruppin H, Sturm G, Westhoff D, Domschke S, Domschke W, Wünsch E, Demling L.
    Journal: Scand J Gastroenterol Suppl; 1976; 39():85-8. PubMed ID: 1069367.
    Abstract:
    In 6 female subjects without gastrointestinal diseases, 13-norleucine motilin (13-Nle-M) synthetic and biological analogue of the duodenal polypeptide, motilin, caused acceleration of intestinal transit time. Intravenous infusion of 0.4 mug/kg-h of 13-Nle-M reduced mean transit time by 50 percent. No side effects occurred during infusion of the polypeptide. Radiographic appearance of small intestinal peristalsis and mucosal relief was not influenced by 13-Nle-M.
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