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  • Title: Dolichin, a new chitinase-like antifungal protein isolated from field beans (Dolichos lablab).
    Author: Ye XY, Wang HX, Ng TB.
    Journal: Biochem Biophys Res Commun; 2000 Mar 05; 269(1):155-9. PubMed ID: 10694493.
    Abstract:
    An antifungal protein, possessing a molecular weight of 28 kDa and an N-terminal sequence resembling chitinases, has been purified from the seeds of the field bean Dolichos lablab. The procedure involved extraction with aqueous buffer, affinity chromatography on Affi-gel blue gel, and ion exchange chromatography on CM-Sepharose. The protein, designated dolichin, exhibited antifungal activity against the fungi Fusarium oxysporum, Rhizoctonia solani, and Coprinus comatus. Dolichin was capable of inhibiting human immunodeficiency virus (HIV) reverse transcriptase and alpha- and beta-glucosidases which are glycohydrolases implicated in HIV infection. It had very low ribonuclease and cell-free translation-inhibitory activities.
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