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  • Title: The use of recombinant human G-CSF in the treatment of propylthiouracil-induced agranulocytosis.
    Author: Altunbas H, Yazicioglu G, Balci MK, Karayalçin U, Undar L.
    Journal: Int J Clin Pract; 1999; 53(5):396-7. PubMed ID: 10695110.
    Abstract:
    A 43-year-old female patient with Basedow-Graves' disease developed agranulocytosis in the eighth month of propylthiouracil therapy. After discontinuing the drug, a broad spectrum antibiotic regimen plus recombinant human granulocyte colony-stimulating factor (G-CSF), a human haematopoietic growth factor, were started. Her granulocyte count returned to normal with the second dose of G-CSF, and ulcerating pharyngitis improved rapidly. We think that in patients with propylthiouracil-induced agranulocytosis, G-CSF will reduce the risk and severity of infection, and should be accepted as a part of the standard therapy.
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