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  • Title: Aqueous humour levels of topically applied ciprofloxacin and ofloxacin in the same subjects.
    Author: Cekiç O, Batman C, Totan Y, Yasar U, Basci NE, Bozkurt A, Kayaalp SO, Zilelioglu O.
    Journal: Eye (Lond); 1999 Oct; 13 ( Pt 5)():656-9. PubMed ID: 10696321.
    Abstract:
    PURPOSE: To evaluate aqueous humour levels of topical 0.3% ciprofloxacin and 0.3% ofloxacin in the same subjects. METHODS: Thirty-two bilateral cataractous patients received topical 0.3% ciprofloxacin in one eye and 0.3% ofloxacin in the other eye before each cataract extraction. Eyedrops were repetitively instilled for 6 h. Aqueous humour samples were collected and assayed for drug concentrations by a method described originally by us using high-performance liquid chromatography. RESULTS: Mean aqueous ciprofloxacin and ofloxacin levels were 0.33 +/- 0.04 microgram/ml (mean +/- SEM) and 1.34 +/- 0.14 micrograms/ml respectively (p < 0.0001). CONCLUSION: Ofloxacin level in the aqueous humour is 4 times higher than that of ciprofloxacin in the same subjects.
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