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  • Title: Studies on muscarinic M2 receptors in smooth muscle.
    Author: Mitchelson F, Shen A.
    Journal: Proc West Pharmacol Soc; 1999; 42():109-10. PubMed ID: 10697708.
    Abstract:
    Histamine after M3 receptor alkylation with 4-DAMP mustard does not serve simply as a spasmogen but facilitates visualization of the M2-mediated contraction induced by oxotremorine M. We speculate that M3 receptor activation has a similar role in untreated tissue. The facilitation appears to involve protein kinase C. The results with propranolol suggest that the phospholipase D pathway may also be important in the development of the M2-mediated response.
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