These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
Pubmed for Handhelds
PUBMED FOR HANDHELDS
Search MEDLINE/PubMed
Title: Targets of oncogenes and tumor suppressors: key for understanding basic mechanisms of carcinogenesis. Author: Kopnin BP. Journal: Biochemistry (Mosc); 2000 Jan; 65(1):2-27. PubMed ID: 10702637. Abstract: Changes in expression of protooncogenes and tumor suppressor genes play a key role in oncogenesis. Dysfunction of their protein products leads to abnormal regulation of signaling pathways, which control the cell cycle, apoptosis, genetic stability, cell differentiation, and morphogenetic reactions. Changes in these important physiological processes are obviously responsible both for initial steps of neoplastic cell transformation and for determination of subsequent tumor progression resulting in the development of malignant tumors.[Abstract] [Full Text] [Related] [New Search]