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  • Title: Reduction in gingival overgrowth associated with conversion from cyclosporin A to tacrolimus.
    Author: James JA, Boomer S, Maxwell AP, Hull PS, Short CD, Campbell BA, Johnson RW, Irwin CR, Marley JJ, Spratt H, Linden GJ.
    Journal: J Clin Periodontol; 2000 Feb; 27(2):144-8. PubMed ID: 10703661.
    Abstract:
    BACKGROUND: Unsightly gingival overgrowth affects many individuals immunosuppressed with cyclosporin A (CsA). Current management involves repeated periodontal surgery and intensive hygienist support. Tacrolimus is an effective alternative immunosuppressive agent for renal transplantation which does not appear to produce gingival enlargement. AIMS: The purpose of the present study was to monitor the gingival response of 4 renal transplant patients (RTPs), with clinically significant CsA-induced gingival overgrowth, after their immunosuppressive therapy was switched to tacrolimus. METHODS: Intra-oral photographs and alginate impressions were taken both prior to the drug conversion and again, 6 to 9 months later. Gingival overgrowth scores were determined, from plaster models on both these occasions. RESULTS: All of the RTPs experienced significant resolution of their gingival enlargement within the time period studied; however, only one had complete regression. CONCLUSION: It is concluded that conversion of RTPs with gingival overgrowth from CsA to tacrolimus may provide an effective management strategy for this clinical problem.
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