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  • Title: Teratological study of the antioxidant stobadine in rats.
    Author: Ujházy E, Dubovický M, Balonová T, Jansák J.
    Journal: Gen Physiol Biophys; 1999 Oct; 18 Spec No():171-6. PubMed ID: 10703736.
    Abstract:
    The potential teratogenicity of the antioxidant stobadine (STO) was studied in Wistar rats. Daily oral doses of 5, 15 and 50 mg/kg STO were given from the 6th day of gestation up to weaning of pups--day 21 post partum. No significant differences between the STO treated groups and the control group were found in litter size, pre- and postimplantation losses and foetal body weight. External, skeletal and internal examinations of the foetuses revealed no evidence of teratogenesis. The offspring from the STO treated dams exhibited a high survival rate in their postnatal development. It can be concluded that STO had no adverse effects on the pre- and postnatal development of the offspring in rats.
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