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  • Title: Production of secretory leucocyte protease inhibitor (SLPI) in human pancreatic beta-cells.
    Author: Nyström M, Bergenfeldt M, Ljungcrantz I, Lindeheim A, Ohlsson K.
    Journal: Mediators Inflamm; 1999; 8(3):147-51. PubMed ID: 10704052.
    Abstract:
    Secretory leucocyte protease inhibitor (SLPI) is a potent inhibitor of granulocyte elastase and cathepsin G, and also an inhibitor of pancreatic enzymes like trypsin, chymotrypsin and pancreatic elastase. SLPI has also been shown to inhibit HIV-1 infections by blocking viral DNA synthesis. Since SLPI is an inhibitor of pancreatic proteases we wished to investigate whether SLPI was also actually produced in the pancreas. M-RNA from human pancreatic tissue showed evidence of SLPI production using the reverse transcriptase polymer chain reaction technique (RT-PCR). Using immunohistochemical methods SLPI was demonstrated in the beta-cells of the islets of Langerhans. The function could be local protease/antiprotease regulation or antiviral/antibacterial defence in the close vicinity of the cell surface, or even inside the beta-cell itself.
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