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  • Title: Interaction with human immunodeficiency virus (HIV) type 2 predicts HIV type 1 genotype.
    Author: Sarr AD, Sankalé JL, Hamel DJ, Travers KU, Guèye-Ndiaye A, Essex M, Mboup S, Kanki PJ.
    Journal: Virology; 2000 Mar 15; 268(2):402-10. PubMed ID: 10704348.
    Abstract:
    In West Africa, India, and certain regions of Europe, both human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2) are known to cocirculate. To investigate the HIV-1 subtypes involved in dual HIV-1 and HIV-2 infections, we sequenced the envelope C2-V3 region from 29 dually infected female commercial sex workers from Senegal. The majority of women (23 of 29) were infected by HIV-1 subtype A. Within the HIV-1 subtype A sequences, 14 of 23 (60.8%) clustered with the West African associated A/G recombinant form (IbNG), and 9 of 23 (39.2%) formed a separate cluster distinct from the A/G IbNG. In contrast, in HIV-1 singly infected individuals, non-IbNG subtype A was found in only 13 of 98 (13.3%). Therefore, the lack of protection and/or interaction with HIV-2 was associated with a distinct HIV-1 A genotype. These results suggest differences in the biological properties of HIV-1 genotypes and their in vivo interaction with HIV-2.
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