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  • Title: Cytotoxic alkaloids of Pachysandra terminalis.
    Author: Funayama S, Noshita T, Shinoda K, Haga N, Nozoe S, Hayashi M, Komiyama K.
    Journal: Biol Pharm Bull; 2000 Feb; 23(2):262-4. PubMed ID: 10706399.
    Abstract:
    Four steroidal alkaloids, epipachysamines B (1) and E (2), pachystermine A (3) and pachysamine E (4), were isolated as cytotoxic principles from the MeOH extract of the stems of Pachysandra terminalis SIEB. et ZUCC. (Buxaceae). These alkaloids showed cytotoxic activity against P388 and P388/ADR leukemia cells in vitro. Three of the alkaloids (1-3) were previously isolated from this plant material, and this is the first report of their cytotoxic activity. Pachysamine E (4) is a new alkaloid.
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