These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Cell to cell interaction between mesangial cells and macrophages induces the expression of monocyte chemoattractant protein-1 through nuclear factor-kappaB activation.
    Author: Hisada Y, Sakurai H, Sugaya T.
    Journal: Biochem Biophys Res Commun; 2000 Mar 16; 269(2):309-16. PubMed ID: 10708548.
    Abstract:
    The interaction between mesangial cells (MCs) and monocytes/macrophages (Mo/Mo) is an important pathogenic feature of glomerulonephritis. However, its mechanism is not fully elucidated. Studies to date have focused on the interactions through mediators. In the present study, to obtain insight into the mechanism of the interaction between MCs and Mo/Mo, we examined the significance of the cell to cell interaction of these cells in the context of monocyte chemoattractant protein-1 (MCP-1) expression using cell contact cultures or co-culture without contact. Our results revealed that the cellular adhesion of cultured macrophages to MCs induced the expression of MCP-1, which was mainly observed in the MCs. In addition, the induction of MCP-1 was, at least in part, mediated by nuclear factor kappa-B activation which occurs preferentially in the MCs. Because MCP-1 is suggested to play an important role in glomerulonephritis, this novel cell to cell interaction between the MCs and Mo/Mo could be important in glomerulonephritis.
    [Abstract] [Full Text] [Related] [New Search]