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  • Title: 5-HT(1A) autoreceptor antagonist-induced 5-HT release in the hamster suprachiasmatic nuclei: effects on circadian clock resetting.
    Author: Antle MC, Glass JD, Mistlberger RE.
    Journal: Neurosci Lett; 2000 Mar 17; 282(1-2):97-100. PubMed ID: 10713405.
    Abstract:
    Serotonin (5-HT) has been implicated in phase shifting of mammalian circadian rhythms by non-photic stimuli. This study tests whether pharmacological induction of endogenous 5-HT release can shift circadian phase in the Syrian hamster. Systemic injections of the 5-HT(1A) antagonist WAY100635 during the mid-subjective day significantly increased 5-HT in dialysate from the hamster suprachiasmatic nucleus (SCN) circadian pacemaker by approximately 50% for 40-60 min. However, this was not associated with phase shifts or with potentiation of phase shifts induced by a 3 h bout of running. These results indicate that enhanced 5-HT release in the SCN or possibly other regions is not sufficient to induce phase shifts in the subjective day.
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