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  • Title: Lymphatic lipid transport is not impaired in ageing rat intestine.
    Author: Hayashi H, Sato Y, Kanai S, Masuda M, Ohta M, Funakoshi A, Nagao K, Imaizumi K, Miyasaka K.
    Journal: Mech Ageing Dev; 2000 Feb 15; 113(3):219-25. PubMed ID: 10714940.
    Abstract:
    Lymphatic lipid transport in the intestine of adult and ageing rats was compared. Adult (8-10 months old) and old (24-26 months old) male Wistar rats were cannulated into the mesenteric lymph under ethrane anesthesia. On the following day, lipid emulsion containing 35.4 mg/h of olive oil was infused intraduodenally for 7 h and lymph collected hourly was assayed for triglyceride and apolipoprotein A-IV (apo A-IV). The results showed there was no difference in lymphatic lipid and apo A-IV transport between adult and old rats. Since apo A-IV synthesis in the enterocytes is linked to the intracellular assembly of lipoprotein, it is likely that in addition to lymphatic transport, production of chylomicrons is not impaired in ageing rats.
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