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  • Title: Haemoglobin concentrations and infection by Giardia intestinalis in children: effect of treatment with secnidazole.
    Author: Jiménez JC, Rodríguez N, Di Prisco MC, Lynch NR, Costa V.
    Journal: Ann Trop Med Parasitol; 1999 Dec; 93(8):823-7. PubMed ID: 10715676.
    Abstract:
    The blood concentrations of haemoglobin were investigated in 82 children aged 2-9 years. Fifty-seven (31 boys and 26 girls) were stool-positive for Giardia intestinalis but the other 25, used as controls, were negative. The mean (S.D.) haemoglobin concentration among the infected children was significantly lower pre-treatment than that for the control group [11.6 (1.2) v. 12.6 (1.5) g/dl; P < 0.05]. Treatment of the infected children with a single oral dose of secnidazole (30 mg/kg) led to a significant increase in their mean haemoglobin level 15 days later, from 11.6 (1.2) g/dl pre-treatment to 12.4 (1.2) g/dl post-treatment (P < 0.05). The results indicate that the therapeutic control of giardiasis could be important in programmes to combat anaemia in children living in endemic areas.
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