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  • Title: [Study of antihypoxic properties and toxicity of mexamine (5-methoxytryptamine)].
    Author: Bykov NP, Strelkov RB, Chizhov AIa.
    Journal: Farmakol Toksikol; 1976; 39(4):451-5. PubMed ID: 1071989.
    Abstract:
    On its introduction to mongrel albino mice in doses of 1 to 200 mg/kg mexamine (5-methoxytryptamine) exerted a marked antihypoxic action in conditions of hypoxic hypoxia (a "rise" in the pressure chamber to an altitude of 8000 to 10 000 m) 5--180 minutes after administration of the drug. The possibility of reducing the toxicity of mexamine through preventive introduction of the agent in a dose of 1 mg/kg was established. With such a modification of the toxicity no mitigation of the antihypoxic effectiveness of the basic dose of the agent is observed.
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