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  • Title: Recognition of human activated CD44 by tumor vasculature-targeted antibody.
    Author: Taniguchi K, Harada N, Ohizumi I, Tsutsumi Y, Nakagawa S, Kaiho Si, Mayumi T.
    Journal: Biochem Biophys Res Commun; 2000 Mar 24; 269(3):671-5. PubMed ID: 10720474.
    Abstract:
    TES-23 monoclonal antibody (MAb), which targets rat CD44H on tumor vascular endothelial cells (TEC), dominantly reacted to human activated CD44 rather than human inactive CD44. TES-23 MAb reacted to HT-1080 fibrosarcoma cells almost comparably to anti-human CD44 MAb and moderately to HUVEC; however, it hardly reacted to PBMC. The binding of soluble hyaluronate to HT-1080 cells and HUVEC was clearly noted, but not to PBMC. In addition, stimulation with phorbol 12-myristate 13-acetate induced soluble hyaluronate binding of MOLT-4 human T lymphoma cells and relatively increased the reactivity of TES-23 MAb. Our results suggest that TES-23 MAb can potentially recognize human activated CD44 and hence might be potentially useful for the treatment of human solid tumors containing TEC that express activated CD44.
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