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  • Title: Simultaneous presence of C-ANCA and P-ANCA in a patient with concurrent Churg-Strauss syndrome and giant cell temporal arteritis.
    Author: Guardiola JM, Rodríguez-Pla A, López-Contreras J, Llobet JM, Domingo P, Franco M, Díaz C, Vázquez G.
    Journal: Scand J Rheumatol; 2000; 29(1):68-9. PubMed ID: 10722262.
    Abstract:
    We herein describe the case of a 77-year-old woman, who presented clinical and histopathological evidence of giant cell arteritis (GCA) involving the temporal artery, together with a Churg-Strauss syndrome (CSS). Our patient presented positive anti-neutrophil cytoplasmic antibodies (ANCA), with cytoplasmic staining pattern (C-ANCA) that was specific against proteinase 3 (PR3), and also a perinuclear pattern (P-ANCA) with specificity against myeloperoxidase (MPO). To our knowledge, the simultaneous presence in the same patient of both types of antibodies has not been previously reported.
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