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  • Title: A novel C-terminal kinesin subfamily may be involved in chromosomal movement in caenorhabditis elegans.
    Author: Ali MY, Siddiqui ZK, Malik AB, Siddiqui SS.
    Journal: FEBS Lett; 2000 Mar 17; 470(1):70-6. PubMed ID: 10722848.
    Abstract:
    C-terminal kinesin motor proteins, such as the Drosophila NCD and yeast KAR3, are involved in chromosomal segregation. Previously we have described two orthologs of NCD in Caenorhabditis elegans, KLP-3 and KLP-17, which also participate in chromosome movement. Here we report cDNA cloning of klp-15 and klp-16, and the expression pattern of the genes encoding C-terminal motor kinesins including klp-15 and klp-16. Interestingly KLP-15 and KLP-16 form a unique class of C-terminal kinesins, distinct from the previously known C-terminal motors in other organisms. Using in situ hybridization and RNA interference assay, we show that although all of these motors mediate chromosome segregation, they do so in a combination of unique and overlapping manners, suggesting a complex hierarchy of kinesin motor function in metazoans.
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