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  • Title: Atypical findings of protein studies using capillary zone electrophoresis.
    Author: Cutlan RT, Smalley DL, Mayer RP, Mullersman JE, Blessum CR.
    Journal: Clin Lab Sci; 1999; 12(6):325-8. PubMed ID: 10724628.
    Abstract:
    We present two atypical cases of protein studies that were evaluated by immunofixation and immunosubtraction using capillary zone electrophoresis and high-resolution agarose gel electrophoresis. The first study showed an abnormal peak in the beta region by capillary zone electrophoresis that was located in the gamma region of the high-resolution agarose gel electrophoresis. Further investigation showed that this monoclonal protein was displaced due to binding with beta-lipoproteins. In the second case, a large peak was detected in the alpha-2 region and was shown by capillary zone electrophoresis to be a non-proteinaceous material that mimicked a paraprotein.
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