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  • Title: A novel t(11;12)(q23-24;q24) in a case of minimally-differentiated acute myeloid leukemia (AML-M0).
    Author: Cox MC, Scanzani A, Del Poeta G, Venditti A, Panetta P, Derme V, Sgro R, Masi M, Amadori S.
    Journal: Cancer Genet Cytogenet; 2000 Apr 01; 118(1):76-9. PubMed ID: 10731597.
    Abstract:
    Acute myeloid leukemia with minimal signs of myeloid differentiation (AML-M0) is a recent addition to the FAB group classification. Chromosome data is scarce, but existing reports describe a high incidence of complex karyotypes and myelodysplastic syndrome-like chromosome alterations, while single chromosome translocations have rarely been reported. We describe the case of a 60-year-old woman diagnosed with AML-M0 with a novel translocation t(11;12)(q23-24;q24) as the sole karyotypic marker. Fluorescence in situ hybridization analysis to assess MLL gene splitting did not show rearrangement of this oncogene.
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