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  • Title: [The effectiveness of G-CSF and GM-CSF in the adjunctive treatment of infections complicating chemotherapy of non-Hodgkin's lymphoma in children. Report of Polish Pediatric Leukemia/Lymphoma Treatment Group].
    Author: Chybicka A, Bogusławska-Jaworska J, Rosińska B, Wecławek-Tompol J, Armata J, Balcerska A, Balwierz W, Bubała H, Drabko K, Eliasińska A, Kedziora M, Sońta-Jakimczyk D, Sopyło B, Kołecki P, Kowalczyk J, Matysiak M, Rokicka-Milewska R, Stefaniak MJ, Stańczak E, Stencel D, Wysocki M, Płoszyńska A.
    Journal: Wiad Lek; 1998; 51 Suppl 4():72-8. PubMed ID: 10731947.
    Abstract:
    Total number of 252 cycles of GM-CSF-Leucomax Sandoz (5 mg/kg/day s.c.) and/or G-CSF Filgrastim Hoffmann-La Roche (5-10 mg/kg/day s.c.) was applied in 124 children aged from 0.5-20 years during neutropenia associated with chemotherapy of non-Hodgkin's lymphoma (NHL). Twenty four children with NHL treated according to the same chemotherapy protocol but without G-CSF and GM-CSF served as a control group. Our study have demonstrated the good efficacy of both G-CSF and GM-CSF therapy. They shortened the period of neutropenia, reduced the number of febrile days, infection's duration and decreased the frequency of infectious complications.
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