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  • Title: [The assessment of the treatment of viral hepatitis C with interferon alpha in children with leukemias and lymphomas].
    Author: Pawelec K, Zielecka-Walewska B, Brojer E, Rokicka-Milewska R.
    Journal: Wiad Lek; 1998; 51 Suppl 4():243-6. PubMed ID: 10731976.
    Abstract:
    Interferon alfa in dose 3-6 MU IM was administered during six months 3 times per week in 30 children with chronic hepatitis C with leukaemias and lymphomas. Chronic hepatitis was diagnosed basing on anti-HCV, RNA HCV by PCR, high activity of ALT and histopathologic examination of the liver. The patients were followed-up for 12 months after IFN therapy. Sustained normalization of ALT levels, together with serum HCV RNA elimination was considered as a complete response and achieved in 33% children. Partial response (ALT normalization without serum HCV RNA elimination) was recorded in 57% patients. Anti HCV antibody was detected in all children during the time of observation.
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