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  • Title: Alpha-fetoprotein production by a malignant mixed Müllerian tumor of the ovary.
    Author: Rebischung C, Pautier P, Morice P, Lhomme C, Duvillard P.
    Journal: Gynecol Oncol; 2000 Apr; 77(1):203-5. PubMed ID: 10739713.
    Abstract:
    Elevated levels of alpha-fetoprotein (AFP), a fetal serum protein, usually signal the development of hepatoma or germ cell tumors, including endodermal sinus tumors. We report the case of a 52-year-old woman with an alpha-fetoprotein-producing malignant mixed Müllerian tumor (MMMT) of the ovary. Serum AFP was 5348 ng/ml at diagnosis. Immunohistochemistry confirmed that the carcinomatous component of this biphasic tumor was the seat of AFP production. After three cycles of combination chemotherapy, the patient achieved a complete remission. Serum AFP was strongly correlated with response to treatment. This is the first report of AFP production by a MMMT of the ovary without a yolk sac component.
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