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  • Title: 1,3-Diarylcycloalkanopyrazoles and diphenyl hydrazides as selective inhibitors of cyclooxygenase-2.
    Author: Sui Z, Guan J, Ferro MP, McCoy K, Wachter MP, Murray WV, Singer M, Steber M, Ritchie DM, Argentieri DC.
    Journal: Bioorg Med Chem Lett; 2000 Mar 20; 10(6):601-4. PubMed ID: 10741562.
    Abstract:
    Novel 1,3-diarylcycloalkanopyrazoles 1, and diphenyl hydrazides 2 were identified as selective inhibitors of cyclooxygenase-2. The 1,3-diaryl substitution pattern of the pyrazole ring in 1 differentiates these compounds from most of the known selective COX-2 inhibitors that contain two aryl rings at the adjacent positions on a heterocyclic or a phenyl ring. Similarly, the two phenyl rings in 2 are also separated by three atoms. SAR of both phenyl rings in 1 and 2, and the aliphatic ring in 1 will be discussed.
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