These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Ara-c induced apoptosis in human myeloid leukemia cell line HL-60].
    Author: Zhou J, Chen Y, Li C.
    Journal: Zhonghua Zhong Liu Za Zhi; 1997 Mar; 19(2):107-10. PubMed ID: 10743072.
    Abstract:
    OBJECTIVE: To elucidate the pattern of chemotherapy drugs induced apoptosis and its role in chemotherapy of acute leukemia. METHODS: Apoptosis induced by Ara-c in human myeloid leukemia cell line HL-60 was investigated by applying light microscopy, electron microscopy combined with DNA electrophoresis and flow cytometry analysis techniques. RESULTS: Apoptosis persisted throughout 36 hours following addition of Ara-c with a gradual augmentation. Efficiency of apoptosis was enhanced in a dose-dependent pattern, HL-60 treated with six other chemotherapy drugs and perpherial white blood cells from a AML case undergoing DA protocol chemotherapy exhibited typical DNA ladder pattern. Further investigation indicated that chemotherapy drugs induced apoptosis came into being possibly by downregulation the oncogenes expression of c-myc and bcl-2. CONCLUSION: Chemotherapy induced apoptosis is a primary mechanism in chemotherapy.
    [Abstract] [Full Text] [Related] [New Search]