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  • Title: Nuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers.
    Author: Srinivasan R, Gillett CE, Barnes DM, Gullick WJ.
    Journal: Cancer Res; 2000 Mar 15; 60(6):1483-7. PubMed ID: 10749108.
    Abstract:
    The prevalence and sites of expression of the c-erbB-4 receptor have been determined by immunocytochemical staining in a series of 178 human breast cancers. Most tumors displayed cytoplasmic staining of variable intensity. When compared with adjacent normal tissue, 32 cases (18%) showed lower than normal expression, and 13 (7%) showed greater than normal expression. Nuclear immunoreactivity, confirmed by two different antibodies, was present in 87 cancers (49%) but was found in normal adjacent breast epithelial cells in <5% of cases. There were no significant associations with cytoplasmic or membrane immunoreactivity, but cases showing nuclear expression in >25% of cells were associated with good histological grade, epidermal growth factor receptor expression, c-erbB-3 positivity, cripto, amphiregulin, and transforming growth factor-alpha overexpression.
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